BioinformaticsBrowser-side scan114-enzyme catalog

Restriction Site Finder

Paste a DNA sequence and scan for common restriction enzyme sites in your browser. Built for quick cloning checks, plasmid map review, and sequence prep before deeper analysis.

Runs locally in your browserFASTA and raw input supportedCommon enzymes first
Sequence input
Paste raw DNA or FASTA text. Whitespace is stripped, U is converted to T, and the scan stays in your browser.
114 enzymes
Enzyme catalog

Search by enzyme or recognition site, then choose exactly what to scan.

20 selected
Analyzed bases: 102Enzymes scanned: 20
FASTA headers and whitespace are removed automatically
Why this page exists
A quick restriction digest check is a natural first step before cloning notes, notebook work, or sequence prep.
Restriction map summary

See which enzymes match, where they cut, and how many sites appear in the sequence.

Browser-side scanning

The sequence is normalized locally, so you can use it for quick checks without a server round-trip.

Built for lab workflows

Designed to support cloning prep and the bioinformatics workflows that later move into Runcell notebooks.

Restriction map
Selected enzymes sorted by site count in the current sequence.
Sites found
12
Enzymes matched
12
Sequence length
102
Enzyme
Recognition
Cut pattern
Overhang
Hits
Positions
BamHI
Common preset
GGATCCG^GATCC
5′ 4-nt
1
12
BglII
Common preset
AGATCTA^GATCT
5′ 4-nt
1
91
EcoRI
Common preset
GAATTCG^AATTC
5′ 4-nt
1
4
HindIII
Common preset
AAGCTTA^AGCTT
5′ 4-nt
1
22
KpnI
Common preset
GGTACCGGTAC^C
3′ 4-nt
1
68
NheI
Common preset
GCTAGCG^CTAGC
5′ 4-nt
1
62
NotI
Common preset
GCGGCCGCGC^GGCCGC
5′ 4-nt
1
47
PstI
Common preset
CTGCAGCTGCA^G
3′ 4-nt
1
39
SacI
Common preset
GAGCTCGAGCT^C
3′ 4-nt
1
74
SalI
Common preset
GTCGACG^TCGAC
5′ 4-nt
1
85
SmaI
Common preset
CCCGGGCCC^GGG
Blunt
1
79
XhoI
Common preset
CTCGAGC^TCGAG
5′ 4-nt
1
30
ApaI
Common preset
GGGCCCGGGCC^C
3′ 4-nt
0
BsaI
Common preset
GGTCTCGGTCTC (1/5)
5′ 4-nt
0
BsmBI
Common preset
CGTCTCCGTCTC (1/5)
5′ 4-nt
0
EcoRV
Common preset
GATATCGAT^ATC
Blunt
0
NcoI
Common preset
CCATGGC^CATGG
5′ 4-nt
0
NdeI
Common preset
CATATGCA^TATG
5′ 2-nt
0
SpeI
Common preset
ACTAGTA^CTAGT
5′ 4-nt
0
XbaI
Common preset
TCTAGAT^CTAGA
5′ 4-nt
0
Restriction map preview
Highlighted bases show every matched recognition motif in the sanitized sequence.
MatchNon-match
1
TTTGAATTCGCGGATCCAAAGAAGCTTCCCTCGAGGGTCTGCAGGGGCGGCCGCATGCAT
61
GGCTAGCGGTACCGAGCTCCCGGGGTCGACAGATCTCATATC
Curated enzyme catalog

The catalog is a versioned snapshot of commercially available enzymes from Biopython restriction data derived from REBASE. Recognition sites support IUPAC ambiguity codes and both DNA strands.

How the scanner works

1. FASTA headers and whitespace are removed.

2. Lowercase input is normalized and U is converted to T.

3. The sequence is scanned on both strands against the selected enzyme motifs in the browser.

What the results mean

Each row shows the recognition motif, the cut pattern, the number of hits, and the 1-based start positions.

Use the copy button to move the table into notes, notebook cells, or a cloning checklist.

Useful next step

After a quick site check, many users move into reverse-complement, GC-content, or concentration calculations before analysis.

Restriction Site Finder FAQ

Answers to the most common sequence-scanning questions.

It scans a DNA sequence for enzyme recognition motifs and reports where each site appears. That makes it easier to plan cloning, digest checks, and plasmid map validation.